DEVELOPMENT OF MICROEMULSION AND WATER/OIL/WATER MULTIPLE EMULSION CONTAINING BETA-ARBUTIN, LACTIC ACID, AND SODIUM ASCORBYL PHOSPHATE

  • SILVIA SURINI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia
  • NUR MPN NEGORO Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

Abstract

Objective: In addition to lactic acid and sodium ascorbyl phosphate, which have whitening effects, beta-arbutin is a safe whitening agent for skin.
Combining these three substances should reduce the concentration of each one in a formula and achieve an optimal whitening effect. In this study,
microemulsions and water/oil/water (W/O/W) multiple emulsions were applied to produce a formula containing these whitening agents.
Methods: All the active ingredients were formulated into microemulsions and W/O/W multiple emulsions with different concentrations of Tween 80
and Span 80 as emulsifiers to obtain a stable formula. Twelve-week physical stability studies were performed for every formula at low (4±2°C), room
(28±2°C), and high (40±2°C) temperatures.
Results: The produced microemulsions were transparent with a mean droplet size of 15.50 nm. In addition, the W/O/W multiple emulsions contained
droplets within droplets, which were dispersed in a continuous phase with an inner droplet size of 0.15 μm and an outer droplet size of 0.37 μm. The
W/O/W multiple emulsions showed pseudoplastic thixotropic flow properties. Furthermore, the microemulsions were stable at low (4±2°C) and
room (28±2°C) temperatures, while the W/O/W multiple emulsions were stable at room (28±2°C) and high (40±2°C) temperatures.
Conclusion: It was concluded that the combination of beta-arbutin, lactic acid, and sodium ascorbyl phosphate was suitable for formulating into
microemulsions as well as W/O/W multiple emulsions as whitening cosmetic products.

Keywords: Beta-arbutin, Lactic acid, Sodium ascorbyl phosphate, Multiple emulsions, Microemulsions

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How to Cite
SURINI, S., & NEGORO, N. M. (2020). DEVELOPMENT OF MICROEMULSION AND WATER/OIL/WATER MULTIPLE EMULSION CONTAINING BETA-ARBUTIN, LACTIC ACID, AND SODIUM ASCORBYL PHOSPHATE. International Journal of Applied Pharmaceutics, 12(1), 212-220. https://doi.org/10.22159/ijap.2020.v12s1.FF048
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