RADIATION THERAPY-INDUCED SUBACUTE INTESTINAL OBSTRUCTION


Rupam G, Balaji O, Sereen Rt, Navin Patil

Abstract


Radiation therapy is an important treatment modality for malignancies of the cervix, uterus, prostate, bladder, testes, and rectum. The incidence of clinically significant radiation-related complications is about 5-20%. Radiation insult to gastrointestinal tract includes damage to the small bowel, colon, and rectum. Predisposing risk factors such as previous surgery, hypertension, diabetes, smoking, hyperbaric oxygen increases the severity of damage as well as the use of other chemotherapeutic agents increases the sensitivity to radiation. Radiation-induced injury can be acute or chronic depending on the mitotic activity of intestinal tissue. Radiation enteritis is usually managed conservatively at the start, but surgery is indicated when complications arise. Hereby, we report a case of subacute intestinal obstruction after 3 weeks of radiotherapy.


Keywords


Intestinal obstruction, Radiotherapy, Radiation enteritis, Adverse reaction.

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References


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About this article

Title

RADIATION THERAPY-INDUCED SUBACUTE INTESTINAL OBSTRUCTION

Keywords

Intestinal obstruction, Radiotherapy, Radiation enteritis, Adverse reaction.

DOI

10.22159/ajpcr.2017.v10i7.18520

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 7 July 2017 Page: 7-8

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

126 Views | 167 Downloads

Authors & Affiliations

Rupam G
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
India

Balaji O
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
India

Sereen Rt
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
India

Navin Patil
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
India


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