IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISM INSULIN-LIKE GROWTH FACTOR TYPE 1 GENE IN VERTICAL MANDIBULAR ASYMMETRY PATIENTS WITH IDIOPATHIC SCOLIOSIS SYMPTOM

Authors

  • Ervina Sofyanti Department of Orthodontic, Faculty of Dentistry, Universitas Sumatera Utara.
  • Dewi Indah Sari Siregar Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara.
  • Otman Siregar Department of Orthopaedic and Traumatology, Haji Adam Malik Hospital.
  • Trelia Boel Department of Dentomaxillofacial Radiography, Faculty of Dentistry, Universitas Sumatera Utara.
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara.
  • Gino Tann Post Graduate School of Medicine, Faculty of Medicine. Universitas Sumatera Utara Medan-North Sumatera, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26686

Keywords:

Vertical mandibular asymmetry, Idiopathic scoliosis symptom, Insulin-like growth factor type 1

Abstract

Objective:Previous studies reported IGF-1 (Insulin-like Growth factor type-1) gene expression in mandibular condylar cartilage and idiopathic scoliosis development. This paper aims to correlate the Single Nucleotide Polymorphism (SNPs) of IGF-1 gene rs5742632 in vertical mandibular asymmetry patients with idiopathic scoliosis symptom.

Methods:TheIGF-1 gene rs5742632 polymorphism of 49 patients (19.38±3.24-year-old) who were treated at orthodontics department Dental Hospital Universitas Sumatera Utara and orthopedics department of Haji Adam Malik Hospital from April-August 2017, were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis in case-control of idiopathic scoliosis symptom. An enzyme-linked immunochemiluminescent assay measured IGF-1 levels. Analyzing of mandibular asymmetry index based on Kjellberg's technique using the panoramic radiograph.

Results:The scoliosis symptom based on clinical judgment of orthopedics by asymmetry trunk posture and adam'sforward bend test movement analysis. This study showed no significant difference (p>0.05) in the genotype distribution (rs5742632) haplotype in vertical mandibular asymmetry based on scoliosis symptom. However, there was a significant difference between early and late adolescent among those subjects in IGF-1 level measurement (p=0.033). dam's forward bend test and a scoliometer measurement

Conclusion:The result was still not conclusive due to variance in mandibular growth and curve lateral spine in adolescent patients. Further study will requiresubject increment and more specific samples to study the risk factor of vertical mandibular asymmetry .

References

Hresko MT. Idiopathic Scoliosis in Adolescents. N Engl J Med 2013;368:834-41.

Horne JP, Flannery R, Usman S. Adolescent idiopathic scoliosis: Diagnosis and management. Am Fam Phys 2014;89:193-8.

Lin H, Zhu P, Lin Y, Wan S, Shu X, Xu Y, et al. Mandibular asymmetry: A three dimensional quantification of bilateral condyles. Head Face Med 2013;9:42.

Meng Q, Long X, Deng M, Cai H, Li J. The expressions of IGF-1, BMP-2 and TGF-β1 in cartilage of condylar hyperplasia. J Oral Rehabil 2011;38:34-40.

Fukaya S, Kanzaki H, Miyamoto Y, Yamaguchi Y, Nakamura Y. Possible alternative treatment for mandibular asymmetry by local unilateral IGF-1 injection into the mandibular condylar cavity: Experimental study in mice. Am J Orthod Dentofacial Orthop 2017;152:820-9.

Giampietro PF. Genetic Aspects of Congenital and Idiopathic Scoliosis. Scientifica; 2012. DOI: org/10.6064/2012/152365.

Yang Y, Wu Z, Zhao T, Wang H, Zhao D, Zhang J, et al. Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes. Orthopedics 2009;32:411.

Gorman KF, Julien C, Moreau A. The genetic epidemiology of idiopathic scoliosis. Eur Spine J 2012;21:1905-19.

Leander D. Role of growth factors in the development of mandible. J Ind Orthod Soc 2011;45:51-60.

Xue F, Wong RW, Rabie AB. Genes, Genetics, and Class III malocclusion. Orthod Craniofac Res 2011;13:69-74.

Chen Y, Ke J, Long X, Meng Q, Deng M, Fang W, et al. Insulin-like growth factor-1 boosts the developing process of condylar hyperplasia by stimulating chondrocytes proliferation. Osteoarthritis Cartilage 2012;20:279-87.

Mak JY, Yap MK, Fung WY, Ng PW, Yip SP. Association of IGF1 gene haplotypes with high myopia in chinese adults. Arch Ophthalmol 2012;130:209-16.

Zhuang W, Yang P, Li Z, Sheng X, Zhao J, Li S, et al. Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population. Mol Vis 2012;18:634-44.

Fuentes R, Engelke W, Bustos L, Oporto G, Borie E, Sandoval P, et al. Reliability of two techniques for measuring condylar asymmetry with X-Rays. Int J Morphol 2011;29:694-701.

Iturriaga V, Pablo N, Mario C, Fuentes R. Prevalence of vertical condilar asymmetry of the temporomandibular joint in patients with signs and symptoms of temporomandibular disorders. Int J Morphol 2012;30:315-21.

Segatto E, Lippold C, Végh A. Craniofacial features of children with spinal deformities. BMC Musculoskelet Disord 2008;9:169.

Zidan HE, Rezk NA, Fouda SM, Mattout HK. Association of insulin-like growth factor-1 gene polymorphisms with different types of myopia in Egyptian patients. Genet Test Mol Biomarkers 2016;20:291-6.

Maki RG. Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol 2010;28:4985-95.

Zhou S, Yan J, Da H, Yang Y, Wang N, Wang W, et al. A correlational study of scoliosis and trunk balance in adult patients with mandibular deviation. PLoS One 2013;8:e59929.

Ben-Bassat Y, Yitschaky M, Kaplan L, Brin I. Occlusal patterns in patients with idiopathic scoliosis. Am J Orthod Dentofacial Orthop 2006;130:629-33.

Lippold C, Danesh G, Hoppe G, Drerup B, Hackenberg L. Trunk inclination, pelvic tilt and pelvic rotation in relation to the craniofacial morphology in adults. Angle Orthod 2007;77:29-35.

Salkar RG, Radke UM, Desmukh SP, Radke PM. Relationships between temporomandibular joint disorders and body posture. Int J Dent Health Sci 2015;2:1523-30.

Maglione HO, de Zavaleta LA, Laraudo J, Falisi G, Fernandez F. Temporomandibular dysfunction: Internal derangement associated with facial and/or mandibular asymmetry. Cranio 2013;31:276-82.

Silvestrini-Biavati A, Migliorati M, Demarziani E, Tecco S, Silvestrini- Biavati P, Polimeni A, et al. Clinical association between teeth malocclusions, wrong posture and ocular convergence disorders: An epidemiological investigation on primary school children. BMC Pediatr 2013;13:12.

Jain S, Jain S, Deoskar A, Prasad VS. Serum IGF-1 levels as a clinical tool for optimizing orthodontic treatment timing. Prog Orthod 2013;14:1-7.

Masoud MI, Marghalani HY, Bamashmous M, Alamoudi NM, Derwi DE, Masoud IM, et al. Predicting changes in mandibular length and total anterior facial height using IGF-1, cervical stage, skeletal classification, and gender. Prog Orthod 2015;16:7.

Gupta S, Deoskar A, Gupta P, Jain S. Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages. Dental Press J Orthod 2015;20:68-75.

Hong JY, Suh SW, Modi HN, Yang JH, Hwang YC, Lee DY, et al. Correlation between facial asymmetry, shoulder imbalance, and adolescent idiopathic scoliosis. Orthopedics 2011;34:187.

Adobor RD, Riise RB, Sørensen R, Kibsgård TJ, Steen H, Brox JI, et al. Scoliosis detection, patient characteristics, referral patterns and treatment in the absence of a screening program in norway. Scoliosis 2012;7:18.

Monaco A, Sgolastra F, Cattaneo R, Petrucci A, Marci MC, D’Andrea PD, et al. Prevalence of myopia in a population with malocclusions. Eur J Paediatr Dent 2012;13:256-8.

Khan MT, Verma SK, Maheshwari S, Zahid SN, Chaudhary PK. Neuromuscular dentistry: Occlusal diseases and posture. J Oral Biol Craniofac Res 2013;2013:1-5.

Published

2018-04-26

How to Cite

Sofyanti, E., D. I. S. Siregar, O. Siregar, T. Boel, D. Satria, and G. Tann. “IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISM INSULIN-LIKE GROWTH FACTOR TYPE 1 GENE IN VERTICAL MANDIBULAR ASYMMETRY PATIENTS WITH IDIOPATHIC SCOLIOSIS SYMPTOM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 100-3, doi:10.22159/ajpcr.2018.v11s1.26686.

Issue

Section

Original Article(s)

Most read articles by the same author(s)

1 2 > >>