COMPARISON OF THE POTENCY OF SEVERAL FLUORIDE-BASED VARNISHES AS AN ANTICARIOGENIC ON CALCIUM, PHOSPHATE, AND FLUORIDE ION LEVELS


Sri Angky Soekanto, Namira Rosithahakiki, Dewi Fatma Suniarti, Mohamad Sahlan

Abstract


Objectives: The purpose of this present study was to analyze several fluoride-based varnishes: Silver diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF). Fluoride-based varnish is proven to act as antibacterial and remineralization agents that arrested caries progression with minimal side effects. SDF, the golden standard for this study, was compared to NSF and PPF, which were made in our own laboratory, to evaluate their ability to release calcium, phosphate, and fluoride ions and act as anticariogenic agents.

Methods: Human dentin discs were prepared and divided into control groups and treatment groups with SDF (38%), NSF (3.16%, 3.66%, and 4.16%), and PPF (3%, 6%, and 10%). The dentin discs were demineralized using a demineralization solution (pH 4.4) for 96 h. Each dentin disc in the treatment group received a topical application of various fluoride-based varnishes and then was subjected to pH-cycling for 8 days. The quantity of calcium, phosphate, and fluoride ions on the dentin discs surface was compared after being detected using energy dispersive X-ray spectroscopy.

Results: The result revealed that the calcium ion levels in groups NSF and PPF increased significantly compared to SDF. The levels of phosphate ions and fluoride ions in groups NSF and PPF increased significantly compared to SDF.

Conclusion: The study concluded that, in contrast to SDF, the prepared NSF and PPF fluoride-based varnishes were shown to release calcium, phosphate, and fluoride ions in this study. Hence, NSF and PPF fluoride-based varnishes are promising as anticariogenic agents.


Keywords


Caries, Calcium ion, Phosphate ion, Fluoride ion, Silver diamine fluoride, Nano silver fluoride, Propolis fluoride, Demineralization, Remineralization.

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About this article

Title

COMPARISON OF THE POTENCY OF SEVERAL FLUORIDE-BASED VARNISHES AS AN ANTICARIOGENIC ON CALCIUM, PHOSPHATE, AND FLUORIDE ION LEVELS

Keywords

Caries, Calcium ion, Phosphate ion, Fluoride ion, Silver diamine fluoride, Nano silver fluoride, Propolis fluoride, Demineralization, Remineralization.

DOI

10.22159/ijap.2017.v9s2.14

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue 2 (Dec.), 2017 Page: 55-59

Online ISSN

0975-7058

Authors & Affiliations

Sri Angky Soekanto
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Namira Rosithahakiki
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Dewi Fatma Suniarti
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Mohamad Sahlan
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jakarta, Indonesia


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