TOXICITY ANALYSIS OF RGD-CHITOSAN FROM SHRIMP SHELL SCAFFOLD MEMBRANES TOWARD HUMAN DENTAL PULP CELLS

  • Mauldina Shabrina Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • Dewi Fatma Suniarti Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • Lisa R Amir Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • Erik Idrus Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Abstract

Objective: This study aimed to analyze RGD-Chitosan from Shrimp Shells’ Scaffolds’ (RCSSS) and CSSS membrane toxicity toward human dental pulp
cells.
Methods: Human dental pulp cells were cultured for 5 days and then exposed to RCSSS or CSSS membranes for 24 hrs. Cell viability was determined
using an MTT assay method.
Results: Cell viability of the RCSSS group and CSSS group was higher than the cell viability of the control group. The cell viability of the RCSSS
group 2 mg (537.39%) was significantly higher than the CSSS group 2 mg (301.74%).
Conclusions: RCSSS membranes were not toxic toward human dental pulp cells and showed better effect toward human dental pulp cells compared
to CSSS membranes.

Keywords: Chitosan, Human dental pulp cells, RGD-chitosan, Toxicity.

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How to Cite
Shabrina, M., Suniarti, D., Amir, L., & Idrus, E. (2017). TOXICITY ANALYSIS OF RGD-CHITOSAN FROM SHRIMP SHELL SCAFFOLD MEMBRANES TOWARD HUMAN DENTAL PULP CELLS. International Journal of Applied Pharmaceutics, 9, 13-16. https://doi.org/10.22159/ijap.2017.v9s1.07_08
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