EFFECTS OF CENTELLA ASIATICA (L.) LEAF EXTRACT ON BONE CALCIUM AND PHOSPHATE LEVELS OF OVARIECTOMIZED RATS

  • YULITA BONG Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia
  • SRI ANGKY SOEKANTO Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia
  • ERIK IDRUS Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia

Abstract

Objective: This study aimed to evaluate the efficacy of Centella asiatica leaf extract in maintaining calcium and phosphate levels in the bone for
preventing osteoporosis in postmenopausal women.
Methods: The obtained C. asiatica leaf extract was administered to ovariectomized rats at the doses of 60, 120, and 180 mg/kg body weight (BW)
for 30 days. Subsequently, the rats were euthanized by ether overdose, and bone calcium and phosphate levels were determined by the wet ashing
technique and spectrophotometry.
Results: The results showed no significant differences in the bone calcium and phosphate levels among rats administered with different doses of
C. asiatica leaf extract.
Conclusion: Our results indicate that C. asiatica leaf extract cannot be used as a source of phytoestrogens to maintain calcium and phosphate levels
in the bones.

Keywords: Bone, calcium, Centella asiatica, Phytoestrogen, Osteoporosis

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How to Cite
BONG, Y., SOEKANTO, S. A., & IDRUS, E. (2019). EFFECTS OF CENTELLA ASIATICA (L.) LEAF EXTRACT ON BONE CALCIUM AND PHOSPHATE LEVELS OF OVARIECTOMIZED RATS. International Journal of Applied Pharmaceutics, 11(1), 67-70. https://doi.org/10.22159/ijap.2019.v11s1.AR169
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