ANTITHROMBOTIC ACTIVITY OF TAMARINDUS INDICA L. IN MICE

  • Fadlina Chany Saputri Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia
  • Chavella Avatara Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
  • Dian Rachmawati Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.

Abstract

Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo).
Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithrombotic
activity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-induced
thromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group.
Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected mice
from thromboembolic death, significantly increasing survival rates in a dose-dependent manner.
Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

Keywords: Antithrombotic, Bleeding time, Survival rate, Tamarindus indica L.

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How to Cite
Saputri, F. C., Avatara, C., & Rachmawati, D. (2018). ANTITHROMBOTIC ACTIVITY OF TAMARINDUS INDICA L. IN MICE. International Journal of Applied Pharmaceutics, 10(1), 35-38. https://doi.org/10.22159/ijap.2018.v10s1.08
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