HEPATOPROTECTIVE EFFECT OF 50% ETHANOL EXTRACT OF SEAGRASS RHIZOME (CYMODOCEA ROTUNDATA) AGAINST LIVER TISSUES IN PARACETAMOL-INDUCED RATS

  • Renita Dewi Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Raesha Dwina Malika Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Ade Mara Meilani Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Fadlina Chany Saputri Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia

Abstract

Objective: This study aimed to determine the hepatoprotective effect of 50% ethanol extract of seagrass rhizome in terms of serum glutamic
oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) activities in paracetamol-induced rat plasma.
Methods: This study included 28 male, white rats randomly divided into seven groups. Groups I and II represented the normal control and control
groups, respectively, administered with 280 mg/kg BW of rhizome extract. Group III represented the negative control group induced by a suspension
of paracetamol (2g/kg BW). Group IV represented a positive control group administered with Hepa-Q® at a dosage of 150 mg/kg BW. Groups V, VI,
and VII were administered with seagrass rhizome extract at doses of 140, 280, and 560 mg/kg BW, respectively, before paracetamol induction. The
test material was orally administered for 17 days. On days 12–17, the rats were induced with paracetamol through the same route. On day 18, blood
sampling was performed followed by SGOT and SGPT plasma measurements.
Results: Our results revealed that seagrass rhizome extracts could significantly decrease SGPT and SGOT levels in paracetamol-induced rats (p<0.05)
compared with those in the negative control group.
Conclusion: Thus, seagrass rhizome extracts possess the potential for development as a hepatoprotective agent.

Keywords: Seagrass rhizome, Hepatoprotective, Paracetamol, Serum glutamic oxaloacetic transaminase, Serum glutamic pyruvic transaminase.

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How to Cite
Dewi, R., Malika, R. D., Meilani, A. M., & Saputri, F. C. (2018). HEPATOPROTECTIVE EFFECT OF 50% ETHANOL EXTRACT OF SEAGRASS RHIZOME (CYMODOCEA ROTUNDATA) AGAINST LIVER TISSUES IN PARACETAMOL-INDUCED RATS. International Journal of Applied Pharmaceutics, 10(1), 240-242. https://doi.org/10.22159/ijap.2018.v10s1.53
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