ANTITHROMBOTIC EFFECT OF TRIGONELLA FOENUM-GRACEUM ON COLLAGEN/ EPINEPHRINE-INDUCED THROMBOEMBOLISM IN MICE

  • Fadlina Chany Saputri Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia
  • Astari Rachma Nityasa Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia

Abstract

Objective: This study aimed to further investigate the antiplatelet and antithrombotic activities of Trigonella foenum-graceum (TFG) in vivo.
Methods: Male mice were divided into two experimental groups (bleeding duration and survival rate). The study groups comprised vehicle controls
(administered carboxymethyl cellulose [CMC]), negative controls (administered CMC), positive controls (administered aspirin), and experimental
treatment groups (administered TFG extract at three doses). Bleeding duration was assessed by excising the tail vein. Survival rate was determined
by inducing thrombosis through intravenous collagen/epinephrine administration.
Results: In mice treated with TFG extract for 7 days, bleeding duration was significantly increased compared with that in controls (p<0.05). Moreover,
mice treated with TFG showed increased survival rates compared with negative controls.
Conclusion: TFG extract showed antithrombotic activity in mice by significantly increasing bleeding duration and survival rate.

Keywords: Antithrombotic, Bleeding duration, Collagen, Epinephrine, Survival rate, Trigonella foenum-graceum.

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Saputri, F. C., & Nityasa, A. R. (2018). ANTITHROMBOTIC EFFECT OF TRIGONELLA FOENUM-GRACEUM ON COLLAGEN/ EPINEPHRINE-INDUCED THROMBOEMBOLISM IN MICE. International Journal of Applied Pharmaceutics, 10(1), 56-58. https://doi.org/10.22159/ijap.2018.v10s1.12
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